Membrane repolarization during cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Membrane repolarization during cardiac muscle cell action potential pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1A1, DDX39A, and TMTC4, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP1A1 grouped by Membrane repolarization during cardiac muscle cell action potential-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ATP1A1 →	-0.483	-1.250	.006	.009	2	12
LIVER	DDX39A →	+0.178	+1.568	.005	.004	2	5
PANCREAS	TMTC4 →	-0.151	-1.121	.009	.008	3	4
STOMACH	KCNH2 →	-0.230	-0.907	.002	.003	1	6
BLOOD_Myeloma	KLHL30 →	+0.210	+1.455	.006	.002	3	4
LUNG_NSCLC_LUAD	GUCY2F →	+0.191	+0.559	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP1A1 by Membrane repolarization during cardiac muscle cell action potential activity — LIVER

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