Membrane depolarization during cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Membrane depolarization during cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHD, GJC1, and MPND, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during cardiac muscle cell action potential activity versus LDHD in STOMACH (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LDHD →	+2.388	+1.055	<.001	.006	3	5
BREAST	GJC1 →	-2.683	-1.045	.006	.005	3	5
SOFT_TISSUE	MPND →	+1.653	+1.974	.008	<.001	3	4
LUNG_SCLC	ESF1 →	-0.570	-1.347	.002	<.001	3	4
LIVER	SIRT2 →	+0.853	+2.021	<.001	<.001	3	4
LIVER	RNF13 →	+0.649	+2.021	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086012 vs LDHD — STOMACH

Explore this scatter interactively →