Membrane repolarization during action potential

Across TCGA cell cohorts, RNA activity of the Membrane repolarization during action potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEMD1, MAL2, and GALNT3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization during action potential activity versus LEMD1 in BLOOD_Lymphoma (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LEMD1 →	+2.341	+0.204	.002	<.001	3	8
PANCREAS	MAL2 →	+5.687	+0.251	<.001	.004	3	7
LUNG_SCLC	GALNT3 →	+2.071	+0.242	.001	.001	3	7
LUNG_SCLC	PARP9 →	+1.386	+0.198	.002	<.001	3	7
STOMACH	ATP1B1 →	+3.461	+0.244	.005	<.001	3	7
LUNG_SCLC	RBM47 →	+2.070	+0.218	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086011 vs LEMD1 — BLOOD_Lymphoma

Explore this scatter interactively →