Membrane depolarization during action potential

Across TCGA cell cohorts, RNA activity of the Membrane depolarization during action potential pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF15, STMN3, and ATAD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF15 grouped by Membrane depolarization during action potential-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TAF15 →	+0.447	+0.990	.009	.004	3	5
LUNG_NSCLC_LUSC	STMN3 →	-2.846	-1.201	.002	<.001	3	4
LIVER	ATAD5 →	+0.692	+1.484	.001	<.001	3	4
LUNG_NSCLC_LUAD	LARP1 →	+0.536	+0.766	<.001	<.001	3	4
LUNG_SCLC	QKI →	+1.808	+0.924	.001	.004	3	4
LUNG_NSCLC_LUAD	MAT2B →	+0.674	+0.904	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF15 by Membrane depolarization during action potential activity — SKIN

Explore this box plot interactively →