Membrane repolarization

Across TCGA cell cohorts, RNA activity of the Membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX60, BST2, and PARP9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization activity versus DDX60 in BREAST (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DDX60 →	+2.038	+0.223	.002	.004	3	7
SKIN	BST2 →	+3.915	+0.141	<.001	<.001	2	7
CNS	PARP9 →	+2.002	+0.225	.005	.001	2	7
CNS	ATP1A1 →	+0.959	+0.221	.004	.001	3	6
BLOOD_Leukemia	CSTA →	+4.774	+0.176	<.001	<.001	3	6
OVARY	INSIG2 →	+1.170	+0.252	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086009 vs DDX60 — BREAST

Explore this scatter interactively →