Ventricular cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Ventricular cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK25, GINS3, and SMG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STK25 grouped by Ventricular cardiac muscle cell action potential-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	STK25 →	+0.648	+1.460	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	GINS3 →	+0.985	+0.985	.007	.007	3	5
UPPER_AERODIGESTIVE_TRACT	SMG5 →	+1.114	+1.504	.001	<.001	3	5
PANCREAS	COPS7B →	+0.601	+1.300	.005	<.001	3	5
BLOOD_Myeloma	FLCN →	+1.190	+1.221	.003	.002	3	4
UPPER_AERODIGESTIVE_TRACT	VPS26C →	+1.031	+1.158	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STK25 by Ventricular cardiac muscle cell action potential activity — OESOPHAGUS

Explore this box plot interactively →