Protein K6-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K6-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP16, FAAP20, and IGF2BP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP16 grouped by Protein K6-linked ubiquitination-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DUSP16 →	+0.886	+0.336	<.001	<.001	3	3
KIDNEY	FAAP20 →	-0.768	-0.381	.008	.004	3	3
LIVER	IGF2BP3 →	-1.297	-1.576	.005	.002	3	3
SKIN	ITGB1 →	-0.852	-0.249	.005	.008	3	3
SKIN	PRRT3 →	-0.693	-0.432	<.001	<.001	3	3
LARGE_INTESTINE	DNAJC16 →	+0.769	+1.154	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP16 by Protein K6-linked ubiquitination activity — SKIN

Explore this box plot interactively →