Lytic vacuole organization

Across TCGA cell cohorts, RNA activity of the Lytic vacuole organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED31, RPAIN, and KATNB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED31 grouped by Lytic vacuole organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MED31 →	+0.849	+1.106	<.001	<.001	3	4
BLOOD_Leukemia	RPAIN →	+0.637	+0.876	.007	.004	3	4
BLOOD_Leukemia	KATNB1 →	+0.762	+1.033	.006	.003	3	4
BLOOD_Leukemia	TMEM256 →	+1.435	+1.203	.002	.001	2	5
STOMACH	UBL3 →	-1.272	-1.476	.003	<.001	3	4
STOMACH	NOMO2 →	-1.300	-1.603	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED31 by Lytic vacuole organization activity — BLOOD_Leukemia

Explore this box plot interactively →