Regulation of fertilization

Across TCGA cell cohorts, RNA activity of the Regulation of fertilization pathway is significantly associated with the drug response of multiple features, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are CDK9_5038, JAK1_8709, and GDC0810, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDK9_5038 grouped by Regulation of fertilization-low versus -high activity in SKIN.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDK9_5038 →	-0.877	-0.250	<.001	.006	3	3
SKIN	JAK1_8709 →	-0.620	-0.350	.015	.002	3	3
SKIN	GDC0810 →	-0.321	-0.184	.002	.004	3	3
SKIN	Dinaciclib →	-0.423	-0.127	.048	.032	3	2
SKIN	Linsitinib →	-0.668	-0.135	.007	.039	3	2
SKIN	N25720-51-A1 →	-0.603	-0.208	.048	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDK9_5038 by Regulation of fertilization activity — SKIN

Explore this box plot interactively →