Intracellular transport of virus

Across TCGA patient cohorts, RNA activity of the Intracellular transport of virus pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMYM1, BCLAF3, and MED23, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular transport of virus activity versus ZMYM1 in UVM (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ZMYM1 →	+0.948	+0.056	<.001	<.001	3	34
UVM	BCLAF3 →	+0.790	+0.054	<.001	<.001	3	33
UVM	MED23 →	+0.963	+0.054	<.001	<.001	3	32
THYM	INO80D →	+0.944	+0.068	<.001	<.001	3	32
CHOL	PRRC2C →	+1.258	+0.073	.001	.005	2	33
UVM	RBM25 →	+1.247	+0.056	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075733 vs ZMYM1 — UVM

Explore this scatter interactively →