Intracellular transport of virus

Across TCGA cell cohorts, RNA activity of the Intracellular transport of virus pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSRP1, TUBB, and ARMH1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular transport of virus activity versus SSRP1 in KIDNEY (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SSRP1 →	+0.916	+0.478	.006	<.001	3	2
KIDNEY	TUBB →	+1.346	+0.506	.001	.002	3	2
KIDNEY	ARMH1 →	-0.665	-0.308	.007	.007	3	2
KIDNEY	FAM71F2 →	-0.750	-0.320	.001	.003	3	2
KIDNEY	GPX3 →	-3.844	-0.320	<.001	.003	3	2
KIDNEY	MGAT4A →	-1.210	-0.320	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075733 vs SSRP1 — KIDNEY

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