IRES-dependent viral translational initiation

Across TCGA patient cohorts, RNA activity of the IRES-dependent viral translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATRX, HTATSF1, and ARID4B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IRES-dependent viral translational initiation activity versus ATRX in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATRX →	+0.297	+0.103	<.001	<.001	3	7
LSCC	HTATSF1 →	+0.265	+0.028	.001	.005	3	6
HNSC	ARID4B →	+0.200	+0.067	<.001	.001	3	6
LSCC	GAR1 →	+0.470	+0.036	<.001	.001	3	6
LSCC	NBEAL2 →	-0.193	-0.032	.004	.005	3	6
LSCC	RCOR3 →	+0.364	+0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075522 vs ATRX — HNSC

Explore this scatter interactively →