IRES-dependent viral translational initiation

Across TCGA pan-cancer cohorts, RNA activity of the IRES-dependent viral translational initiation pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IRES-dependent viral translational initiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and LUSC, show the opposite pattern, with higher activity associated with better survival.

KIRC, ACC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.506	0.727	<.001	145	view →
ACC	DFS	Median	All	0.208	0.658	<.001	95	view →
KIRP	DFS	Median	All	0.436	0.722	<.001	85	view →
KICH	DFS	Quartile	II,III,IV	0.370	1.000	.005	51	view →
LIHC	OS	Median	All	0.681	0.847	<.001	39	view →
THCA	DFS	Quartile	II,III,IV	0.779	0.922	.007	36	view →
UVM	DFS	Median	III,IV	0.267	0.796	.002	32	view →
READ	OS	Tertile	II,III,IV	0.760	0.497	.009	30	view →
LGG	DFS	Quartile	All	0.784	0.903	<.001	29	view →
LUSC	DFS	Median	All	0.707	0.590	.011	27	view →
BLCA	OS	Median	All	0.562	0.780	.002	24	view →
SKCM	OS	Quartile	All	0.354	0.201	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0075522–KIRC (OS)

Open the KIRC breakdown →