IRES-dependent viral translational initiation

Across TCGA patient cohorts, RNA activity of the IRES-dependent viral translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZWINT, MTCO1P29, and SUPT4H1P1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IRES-dependent viral translational initiation activity versus ZWINT in PDAC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZWINT →	+0.438	+0.121	.005	.005	3	3
PDAC	MTCO1P29 →	+0.468	+0.109	<.001	.003	3	3
CCRCC	SUPT4H1P1 →	+0.444	+0.109	.001	.001	3	3
GBM	CSTF2 →	+0.276	+0.098	.001	.005	3	3
GBM	KHDRBS2 →	-0.829	-0.129	<.001	<.001	3	3
GBM	KCNMA1 →	-0.481	-0.104	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075522 vs ZWINT — PDAC

Explore this scatter interactively →