IRES-dependent viral translational initiation

Across TCGA patient cohorts, RNA activity of the IRES-dependent viral translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSTF1, ANK2_S890, and MAP4K2_T296, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IRES-dependent viral translational initiation activity versus CSTF1 in GBM (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSTF1 →	+0.291	+0.189	<.001	<.001	3	3
UCEC	ANK2_S890 →	-0.633	-0.095	<.001	.001	3	3
UCEC	MAP4K2_T296 →	-0.917	-0.227	<.001	<.001	3	3
OV	HNRNPK_S284 →	+0.409	+0.213	<.001	<.001	3	3
HNSC	DDX21 →	+0.429	+0.180	<.001	<.001	3	3
GBM	HNRNPC →	+0.268	+0.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075522 vs CSTF1 — GBM

Explore this scatter interactively →