IRES-dependent viral translational initiation

Across TCGA cell cohorts, RNA activity of the IRES-dependent viral translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZRANB2, TRAF5, and CD83, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZRANB2 grouped by IRES-dependent viral translational initiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZRANB2 →	+1.046	+0.273	<.001	<.001	3	4
BONE	TRAF5 →	+1.804	+0.270	.007	.004	3	4
LUNG_NSCLC_LUAD	CD83 →	+0.843	+0.119	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SKIV2L →	+0.885	+0.153	<.001	.001	3	4
LARGE_INTESTINE	DENND6A →	-0.610	-0.130	.001	.006	2	4
BLOOD_Leukemia	BYSL →	+0.790	+0.241	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZRANB2 by IRES-dependent viral translational initiation activity — BLOOD_Leukemia

Explore this box plot interactively →