IRES-dependent viral translational initiation

Across TCGA cell cohorts, RNA activity of the IRES-dependent viral translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC86, PTPN11, and RUVBL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IRES-dependent viral translational initiation activity versus CCDC86 in PANCREAS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CCDC86 →	+1.222	+0.407	<.001	.004	3	7
KIDNEY	PTPN11 →	+0.892	+0.290	.002	.005	3	6
PANCREAS	RUVBL1 →	+0.906	+0.501	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	DTD2 →	+1.298	+0.654	.001	<.001	3	5
LIVER	GIT2 →	+0.821	+0.452	<.001	<.001	3	5
OVARY	HSPA4L →	+1.356	+0.381	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075522 vs CCDC86 — PANCREAS

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