Response to sorbitol

Across TCGA patient cohorts, RNA activity of the Response to sorbitol pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRIX1, MCM2, and NUP155_S992, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sorbitol activity versus BRIX1 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BRIX1 →	+0.312	+0.063	<.001	<.001	3	8
LSCC	MCM2 →	+0.671	+0.097	<.001	<.001	3	8
BRCA	NUP155_S992 →	+0.338	+0.046	<.001	<.001	3	8
HNSC	TFB1M →	+0.334	+0.079	<.001	<.001	3	7
COAD	PRKDC →	+0.232	+0.041	.005	.003	3	7
LUAD	RRM2 →	+0.762	+0.068	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072708 vs BRIX1 — LSCC

Explore this scatter interactively →