Response to sorbitol

Across TCGA patient cohorts, RNA activity of the Response to sorbitol pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM2, MRPL23, and MYLK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sorbitol activity versus PDLIM2 in COAD (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDLIM2 →	-0.219	-0.678	.008	<.001	3	3
COAD	MRPL23 →	+0.458	+0.615	.001	.005	3	3
COAD	MYLK →	-0.657	-0.535	.003	.002	3	3
HNSC	ITFG1-AS1 →	-0.541	-0.676	.001	.005	3	3
PDAC	ASH1L →	-0.287	-0.609	.007	.003	2	4
PDAC	RNVU1-2A →	-0.515	-0.480	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072708 vs PDLIM2 — COAD

Explore this scatter interactively →