Response to sorbitol

Across TCGA cell cohorts, RNA activity of the Response to sorbitol pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSR1, SULT1A1, and STK17B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sorbitol activity versus MSR1 in LUNG_SCLC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MSR1 →	+1.283	+0.318	<.001	.006	3	3
BLOOD_Lymphoma	SULT1A1 →	+3.419	+0.316	<.001	.005	3	3
LUNG_SCLC	STK17B →	+0.762	+0.281	.003	.001	3	2
BLOOD_Lymphoma	WASHC2A →	-0.540	-0.316	<.001	.005	3	2
OESOPHAGUS	ZNF230 →	-0.613	-0.385	.007	.004	3	2
OESOPHAGUS	ZNF526 →	-0.676	-0.411	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072708 vs MSR1 — LUNG_SCLC

Explore this scatter interactively →