T cell extravasation

Across TCGA cell cohorts, RNA activity of the T cell extravasation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRCAP, PHACTR2, and NPAS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRCAP grouped by T cell extravasation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PTPRCAP →	+0.728	+1.591	<.001	<.001	3	5
BLOOD_Leukemia	PHACTR2 →	-1.460	-1.046	.004	.005	3	4
BLOOD_Myeloma	NPAS1 →	+1.200	+1.325	.006	.003	3	4
BLOOD_Lymphoma	MAN1A1 →	-4.483	-2.070	<.001	<.001	3	3
BLOOD_Lymphoma	ABHD5 →	-2.216	-1.947	.002	<.001	3	3
BLOOD_Lymphoma	TMEM63B →	-1.730	-1.967	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRCAP by T cell extravasation activity — LIVER

Explore this box plot interactively →