Lymphocyte migration

Across TCGA cell cohorts, RNA activity of the Lymphocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM131L, PAQR3, and SUPT16H, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte migration activity versus TMEM131L in BLOOD_Lymphoma (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TMEM131L →	-1.771	-0.278	<.001	<.001	3	6
BLOOD_Leukemia	PAQR3 →	-0.854	-0.183	.004	.008	3	5
OVARY	SUPT16H →	-0.961	-0.321	.002	.009	3	5
KIDNEY	GPATCH11 →	-0.696	-0.248	<.001	<.001	3	5
KIDNEY	HSPA13 →	-0.940	-0.223	.001	.008	3	5
BLOOD_Leukemia	BLOC1S3 →	+0.413	+0.244	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072676 vs TMEM131L — BLOOD_Lymphoma

Explore this scatter interactively →