Osteoclast fusion

Across TCGA patient cohorts, RNA activity of the Osteoclast fusion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF365, SH3PXD2A, and ACTA2-AS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoclast fusion activity versus ZNF365 in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF365 →	+0.645	+0.258	<.001	.003	3	8
OV	SH3PXD2A →	+1.131	+0.185	<.001	<.001	3	8
OV	ACTA2-AS1 →	+1.405	+0.235	<.001	<.001	3	7
BRCA	DNM3OS →	+1.023	+0.194	<.001	<.001	3	7
OV	SPARC →	+1.411	+0.281	<.001	<.001	3	7
BRCA	LAYN →	+0.840	+0.216	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072675 vs ZNF365 — LSCC

Explore this scatter interactively →