Multinuclear osteoclast differentiation

Across TCGA patient cohorts, RNA activity of the Multinuclear osteoclast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FHL2, CNN2, and TAGLN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multinuclear osteoclast differentiation activity versus FHL2 in GBM (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FHL2 →	+0.807	+0.127	<.001	<.001	3	8
OV	CNN2 →	+0.598	+0.088	<.001	<.001	3	8
OV	TAGLN →	+1.164	+0.127	<.001	<.001	3	7
BRCA	TPM4 →	+0.478	+0.084	<.001	<.001	3	7
UCEC	ACTN1 →	+0.425	+0.099	.003	.001	3	7
OV	TUBB6 →	+0.479	+0.115	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072674 vs FHL2 — GBM

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