Multinuclear osteoclast differentiation

Across TCGA patient cohorts, RNA activity of the Multinuclear osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3PXD2A, ACTA2-AS1, and DNM3OS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multinuclear osteoclast differentiation activity versus SH3PXD2A in BRCA (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH3PXD2A →	+0.825	+0.273	<.001	<.001	3	8
OV	ACTA2-AS1 →	+1.337	+0.218	.002	.002	3	6
BRCA	DNM3OS →	+1.200	+0.200	<.001	<.001	3	6
COAD	COL10A1 →	+1.965	+0.222	<.001	<.001	3	6
BRCA	VIM →	+1.000	+0.215	<.001	<.001	3	6
LSCC	ZNF365 →	+0.561	+0.272	.003	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072674 vs SH3PXD2A — BRCA

Explore this scatter interactively →