Multinuclear osteoclast differentiation

Across TCGA cell cohorts, RNA activity of the Multinuclear osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYRK3, KCNG1, and CLPX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DYRK3 grouped by Multinuclear osteoclast differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DYRK3 →	+0.942	+1.001	.002	.005	3	4
BLOOD_Leukemia	KCNG1 →	+2.275	+1.329	.006	.006	3	4
LUNG_SCLC	CLPX →	+1.019	+1.432	.001	.008	3	4
LIVER	LRGUK →	+0.145	+2.110	.005	.003	3	4
STOMACH	HLA-DOB →	-0.962	-1.370	<.001	<.001	3	4
OESOPHAGUS	SLC47A1 →	+2.307	+1.022	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DYRK3 by Multinuclear osteoclast differentiation activity — CNS

Explore this box plot interactively →