Lamellipodium morphogenesis

Across TCGA cell cohorts, RNA activity of the Lamellipodium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM23, ZHX1, and CCDC28A-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAM23 grouped by Lamellipodium morphogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ADAM23 →	-3.245	-1.822	<.001	<.001	3	4
LUNG_SCLC	ZHX1 →	+1.577	+1.536	.007	<.001	3	4
OESOPHAGUS	CCDC28A-AS1 →	+0.442	+1.236	.008	.008	3	4
STOMACH	AK2 →	-0.436	-1.415	.004	<.001	3	3
BREAST	GBE1 →	-1.679	-0.881	.001	.008	3	3
BREAST	HOOK1 →	+1.168	+0.950	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAM23 by Lamellipodium morphogenesis activity — BONE

Explore this box plot interactively →