Establishment of protein localization to vacuole

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to vacuole pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMT5B, MED1, and AKAP9, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to vacuole activity versus KMT5B in UVM (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	KMT5B →	+1.186	+0.046	<.001	<.001	3	34
KICH	MED1 →	+1.136	+0.024	<.001	<.001	3	34
UVM	AKAP9 →	+1.801	+0.047	<.001	<.001	3	34
THYM	ROCK2 →	+1.318	+0.073	<.001	<.001	3	34
THYM	DENND4C →	+1.939	+0.079	<.001	<.001	3	34
THYM	KIAA1109 →	+1.643	+0.078	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072666 vs KMT5B — UVM

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