Establishment of protein localization to vacuole

Across TCGA pan-cancer cohorts, RNA activity of the Establishment of protein localization to vacuole pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 65 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Establishment of protein localization to vacuole pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, SKCM, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.404	0.261	.003	65	view →
SKCM	OS	Tertile	All	0.434	0.283	<.001	53	view →
BRCA	DFS	Quartile	III,IV	0.919	0.686	<.001	46	view →
DLBC	DFS	Median	All	0.542	1.000	.003	31	view →
MESO	DFS	Tertile	IV	0.068	0.535	.002	30	view →
THYM	DFS	Tertile	All	1.000	0.645	.014	22	view →
ESCA	OS	Median	III,IV	0.608	0.324	.012	18	view →
PAAD	OS	Tertile	II,III,IV	0.877	0.521	.017	17	view →
LIHC	OS	Median	All	0.611	0.759	.006	16	view →
KIRC	DFS	Tertile	II,III,IV	0.302	0.610	.004	15	view →
THCA	OS	Median	IV	0.576	1.000	.001	13	view →
TGCT	DFS	Quartile	All	1.000	0.726	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0072666–HNSC (DFS)

Open the HNSC breakdown →