Establishment of protein localization to vacuole

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to vacuole pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL3, RPL4, and RPL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to vacuole activity versus RPL3 in BRCA (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL3 →	-0.247	-0.024	<.001	<.001	3	5
BRCA	RPL4 →	-0.276	-0.030	<.001	<.001	3	5
BRCA	RPL5 →	-0.216	-0.041	<.001	<.001	3	5
BRCA	BBS2 →	+0.325	+0.020	<.001	.004	3	5
LUAD	MRPS18B →	-0.208	-0.027	.002	.001	3	5
PDAC	MTR →	+0.237	+0.027	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072666 vs RPL3 — BRCA

Explore this scatter interactively →