Establishment of protein localization to vacuole

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to vacuole pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQSTM1, EMB, and KLHL6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to vacuole activity versus SQSTM1 in UCEC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SQSTM1 →	+1.099	+0.161	.003	.001	3	5
LUAD	EMB →	+0.802	+0.172	<.001	.001	3	5
HNSC	KLHL6 →	+0.548	+0.079	.001	.008	3	5
UCEC	HEXB →	+0.518	+0.132	.007	.002	3	5
GBM	SNX20 →	+0.431	+0.088	.004	<.001	3	5
GBM	ADORA3 →	+0.827	+0.112	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072666 vs SQSTM1 — UCEC

Explore this scatter interactively →