Establishment of protein localization to vacuole

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to vacuole pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM102A, ELP6, and TRMU, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM102A grouped by Establishment of protein localization to vacuole-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM102A →	+0.982	+0.215	.001	.002	3	4
BLOOD_Myeloma	ELP6 →	-1.519	-0.487	.001	.003	3	4
BLOOD_Lymphoma	TRMU →	-0.548	-0.325	.005	.001	3	4
OESOPHAGUS	RBFA →	-1.189	-0.346	<.001	<.001	3	4
LUNG_NSCLC_LUAD	C1orf116 →	+1.636	+0.272	<.001	.004	3	4
STOMACH	SPPL2A →	+1.131	+0.227	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM102A by Establishment of protein localization to vacuole activity — BREAST

Explore this box plot interactively →