Maintenance of protein localization in organelle

Across TCGA patient cohorts, RNA activity of the Maintenance of protein localization in organelle pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K2, PIAS1, and BOD1L1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein localization in organelle activity versus MAP3K2 in UVM (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	MAP3K2 →	+1.584	+0.067	<.001	<.001	3	34
UVM	PIAS1 →	+1.109	+0.070	<.001	<.001	3	34
THYM	BOD1L1 →	+1.401	+0.059	<.001	<.001	3	34
DLBC	EP300 →	+1.590	+0.071	<.001	<.001	3	33
UVM	HIPK3 →	+1.474	+0.069	<.001	<.001	3	33
THYM	ASH1L →	+1.162	+0.045	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072595 vs MAP3K2 — UVM

Explore this scatter interactively →