Maintenance of protein localization in organelle

Across TCGA pan-cancer cohorts, RNA activity of the Maintenance of protein localization in organelle pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 40 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Maintenance of protein localization in organelle pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and ESCA, show the opposite pattern, with higher activity associated with better survival.

SKCM, LUSC, and LAML are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.493	0.307	.005	29	view →
LUSC	DFS	Quartile	III,IV	0.284	0.935	.001	27	view →
LAML	DFS	Tertile	All	0.234	0.574	.022	24	view →
UCS	DFS	Tertile	IV	0.132	0.613	.045	24	view →
ESCA	OS	Median	III,IV	0.662	0.336	.009	20	view →
LIHC	DFS	Median	All	0.467	0.605	.005	18	view →
CHOL	DFS	Median	II,III,IV	0.093	0.510	.002	18	view →
ACC	DFS	Median	All	0.552	0.844	.008	17	view →
LGG	DFS	Median	All	0.204	0.491	.002	16	view →
SCLC	DFS	Tertile	All	0.410	0.876	.010	10	view →
UCEC	DFS	Quartile	IV	0.691	0.283	.022	8	view →
UVM	OS	Median	III,IV	0.288	0.899	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0072595–SKCM (OS)

Open the SKCM breakdown →