Maintenance of protein localization in organelle

Across TCGA patient cohorts, RNA activity of the Maintenance of protein localization in organelle pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NFATC2, LMOD1_S85, and NCOA7_S89, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein localization in organelle activity versus NFATC2 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NFATC2 →	+0.363	+0.043	<.001	<.001	3	7
CCRCC	LMOD1_S85 →	+1.104	+0.047	<.001	<.001	3	7
BRCA	NCOA7_S89 →	+0.721	+0.032	<.001	.001	3	7
LSCC	RPS2 →	-0.157	-0.038	<.001	.001	3	6
OV	DAB2_S723 →	+0.905	+0.040	.001	<.001	3	6
OV	DPYD →	+0.516	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072595 vs NFATC2 — GBM

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