Maintenance of protein localization in organelle

Across TCGA patient cohorts, RNA activity of the Maintenance of protein localization in organelle pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF13B, APOBEC3G, and IRF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein localization in organelle activity versus TNFSF13B in HNSC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TNFSF13B →	+0.816	+0.157	<.001	<.001	3	7
HNSC	APOBEC3G →	+0.656	+0.137	.009	.002	3	7
LSCC	IRF1 →	+0.500	+0.182	.003	<.001	3	7
COAD	CYTH4 →	+0.457	+0.090	.001	.001	3	6
COAD	LILRB1 →	+0.482	+0.096	<.001	<.001	3	6
COAD	CCL8 →	+0.986	+0.110	.006	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072595 vs TNFSF13B — HNSC

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