Maintenance of protein localization in organelle

Across TCGA cell cohorts, RNA activity of the Maintenance of protein localization in organelle pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNG3, FAM91A1, and PPP1R12A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNG3 grouped by Maintenance of protein localization in organelle-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KCNG3 →	+0.345	+0.114	.008	.007	3	7
LUNG_NSCLC_LUSC	FAM91A1 →	-0.255	-0.176	<.001	.005	3	6
LIVER	PPP1R12A →	+0.393	+0.127	.004	.004	3	5
CNS	PSMB6 →	-0.338	-0.064	.002	.002	3	5
STOMACH	ZNF26 →	-0.372	-0.102	.002	.005	3	5
BREAST	SLIRP →	-0.218	-0.082	.009	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNG3 by Maintenance of protein localization in organelle activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →