Maintenance of protein localization in organelle

Across TCGA cell cohorts, RNA activity of the Maintenance of protein localization in organelle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOSTRIN, GRTP1, and TRRAP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein localization in organelle activity versus NOSTRIN in LUNG_SCLC (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NOSTRIN →	-0.828	-0.213	.004	<.001	3	6
LARGE_INTESTINE	GRTP1 →	-1.845	-0.209	.001	.006	3	5
SKIN	TRRAP →	-1.072	-0.167	.003	.008	2	6
LUNG_NSCLC_LUAD	SH3BGRL3 →	+1.195	+0.148	.001	<.001	3	5
URINARY_TRACT	RHOA →	+0.744	+0.193	.001	.001	3	4
BONE	DGKG →	+3.167	+0.119	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072595 vs NOSTRIN — LUNG_SCLC

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