Reactive oxygen species metabolic process

Across TCGA patient cohorts, RNA activity of the Reactive oxygen species metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIP4K2A, PDLIM3, and TANGO2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reactive oxygen species metabolic process activity versus PIP4K2A in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIP4K2A →	+0.624	+0.047	<.001	<.001	3	9
COAD	PDLIM3 →	+0.570	+0.028	<.001	<.001	3	9
GBM	TANGO2 →	+0.427	+0.059	<.001	<.001	3	8
OV	CCNL1_S374 →	-0.560	-0.023	.001	<.001	3	8
BRCA	LETM1 →	-0.453	-0.024	<.001	<.001	3	8
GBM	SNTB2_S222 →	+0.946	+0.049	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072593 vs PIP4K2A — GBM

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