Neurotransmitter-gated ion channel clustering

Across TCGA patient cohorts, RNA activity of the Neurotransmitter-gated ion channel clustering pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM63A, DBN1, and SPINT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter-gated ion channel clustering activity versus TMEM63A in BRCA (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMEM63A →	-0.401	-0.032	<.001	<.001	3	5
GBM	DBN1 →	+0.262	+0.066	<.001	<.001	3	5
BRCA	SPINT1 →	-0.467	-0.045	<.001	<.001	3	5
COAD	C1QC →	+0.674	+0.047	<.001	<.001	3	5
COAD	PAFAH1B1 →	+0.201	+0.026	<.001	.002	3	5
HNSC	NCAM1 →	+0.724	+0.046	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072578 vs TMEM63A — BRCA

Explore this scatter interactively →