Neurotransmitter-gated ion channel clustering

Across TCGA patient cohorts, RNA activity of the Neurotransmitter-gated ion channel clustering pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAMP2, EMCN, and TEK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter-gated ion channel clustering activity versus RAMP2 in CCRCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RAMP2 →	+0.889	+0.733	<.001	<.001	3	8
CCRCC	EMCN →	+1.187	+0.969	<.001	<.001	3	8
CCRCC	TEK →	+1.312	+1.185	<.001	<.001	3	7
CCRCC	CLEC14A →	+1.009	+0.806	<.001	<.001	3	7
CCRCC	ECSCR →	+0.655	+0.726	<.001	<.001	3	7
CCRCC	FHL5 →	+0.778	+0.675	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072578 vs RAMP2 — CCRCC

Explore this scatter interactively →