Neurotransmitter-gated ion channel clustering

Across TCGA cell cohorts, RNA activity of the Neurotransmitter-gated ion channel clustering pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCN7, ZNF93, and NFKB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLCN7 grouped by Neurotransmitter-gated ion channel clustering-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CLCN7 →	-0.959	-1.893	.001	<.001	3	4
OVARY	ZNF93 →	+1.409	+0.998	.006	.007	3	4
OVARY	NFKB2 →	-1.085	-1.247	.005	.003	3	4
LUNG_SCLC	CLHC1 →	+0.887	+0.366	<.001	<.001	3	4
STOMACH	MMP2 →	+3.461	+1.286	<.001	.006	3	4
SOFT_TISSUE	FAM227A →	-0.880	-1.437	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLCN7 by Neurotransmitter-gated ion channel clustering activity — BONE

Explore this box plot interactively →