Endothelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Endothelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUS4L, ERLIN1, and SDCBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUS4L grouped by Endothelial cell apoptotic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DUS4L →	-0.538	-0.898	.005	.005	3	3
LUNG_NSCLC_LUSC	ERLIN1 →	+1.404	+1.425	<.001	.001	3	3
SOFT_TISSUE	SDCBP2 →	-0.594	-0.772	<.001	.003	3	3
STOMACH	CEP290 →	-0.524	-0.892	.002	.001	3	3
OESOPHAGUS	NEK8 →	+0.816	+0.809	.008	.008	3	3
OESOPHAGUS	SHISA5 →	+0.893	+1.085	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUS4L by Endothelial cell apoptotic process activity — LARGE_INTESTINE

Explore this box plot interactively →