T-helper 17 cell lineage commitment

Across TCGA patient cohorts, RNA activity of the T-helper 17 cell lineage commitment pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRF4, STAT3_S701, and ZBTB34_S164, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 17 cell lineage commitment activity versus IRF4 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRF4 →	+0.636	+0.466	<.001	<.001	3	4
BRCA	STAT3_S701 →	+1.173	+0.285	<.001	<.001	3	3
BRCA	ZBTB34_S164 →	+0.856	+0.331	<.001	.002	3	3
OV	SETX_T2474 →	+0.611	+0.662	<.001	<.001	3	3
UCEC	BAK1 →	-0.354	-0.476	<.001	.002	3	3
OV	ALG2 →	+0.338	+0.767	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072540 vs IRF4 — LSCC

Explore this scatter interactively →