Fibroblast activation

Across TCGA patient cohorts, RNA activity of the Fibroblast activation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S102, PRKG1, and SPARCL1_S198, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast activation activity versus TNS2_S102 in OV (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNS2_S102 →	+0.956	+0.057	<.001	<.001	3	10
OV	PRKG1 →	+0.859	+0.074	<.001	<.001	3	10
BRCA	SPARCL1_S198 →	+1.131	+0.086	<.001	<.001	3	10
OV	RSU1 →	+0.464	+0.082	<.001	<.001	3	9
BRCA	SERPINA5 →	+0.569	+0.059	<.001	<.001	3	9
GBM	STAB1 →	+0.618	+0.078	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072537 vs TNS2_S102 — OV

Explore this scatter interactively →