Purine-containing compound transmembrane transport

Across TCGA patient cohorts, RNA activity of the Purine-containing compound transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, LCP2, and LPXN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine-containing compound transmembrane transport activity versus WAS in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAS →	+0.431	+0.033	<.001	<.001	3	9
UCEC	LCP2 →	+0.523	+0.051	<.001	<.001	3	8
GBM	LPXN →	+0.650	+0.044	<.001	<.001	3	8
GBM	LSP1 →	+0.665	+0.037	<.001	<.001	3	8
UCEC	WIPF1 →	+0.424	+0.041	<.001	<.001	3	8
LSCC	ALOX5 →	+0.486	+0.043	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072530 vs WAS — GBM

Explore this scatter interactively →