Pyrimidine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL7, RRBP1, and MRPS10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound catabolic process activity versus RPL7 in HNSC (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL7 →	-0.173	-0.042	<.001	<.001	3	5
LSCC	RRBP1 →	-0.339	-0.033	<.001	<.001	3	5
OV	MRPS10 →	-0.404	-0.045	.002	<.001	3	5
CCRCC	KANK2 →	+0.371	+0.037	.008	.002	3	5
CCRCC	NDUFAF2 →	-0.355	-0.037	.001	.001	3	5
CCRCC	PRIMPOL_S255 →	+0.276	+0.032	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072529 vs RPL7 — HNSC

Explore this scatter interactively →