Pyrimidine-containing compound catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Pyrimidine-containing compound catabolic process pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 42 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Pyrimidine-containing compound catabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SCLC, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.416	0.792	<.001	108	view →
KIRC	OS	Tertile	All	0.541	0.748	<.001	108	view →
HNSC	DFS	Tertile	IV	0.435	0.277	.002	58	view →
SCLC	DFS	Median	All	0.774	0.502	.002	57	view →
LGG	OS	Median	All	0.699	0.901	<.001	54	view →
ACC	DFS	Quartile	All	0.304	0.870	<.001	54	view →
BRCA	OS	Quartile	All	0.687	0.507	<.001	41	view →
CESC	OS	Tertile	All	0.872	0.726	.010	30	view →
LUAD	DFS	Median	IV	0.327	0.761	.001	24	view →
ESCA	DFS	Median	III,IV	0.448	0.239	.010	21	view →
SKCM	OS	Median	All	0.422	0.282	.008	21	view →
PAAD	OS	Tertile	All	0.257	0.557	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0072529–UVM (DFS)

Open the UVM breakdown →