Pyrimidine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAM, BTK, and PIK3R5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound catabolic process activity versus ITGAM in COAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ITGAM →	+0.935	+0.197	<.001	<.001	3	6
CCRCC	BTK →	+0.653	+0.193	<.001	<.001	3	5
CCRCC	PIK3R5 →	+0.472	+0.190	<.001	<.001	3	5
HNSC	SAMSN1 →	+0.640	+0.139	.009	.004	3	5
CCRCC	CSF1R →	+0.516	+0.154	<.001	<.001	3	5
HNSC	PIK3R6 →	+0.798	+0.114	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072529 vs ITGAM — COAD

Explore this scatter interactively →