Pyrimidine-containing compound catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS2, GLIPR1, and NPHP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound catabolic process activity versus RBMS2 in LUNG_SCLC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RBMS2 →	-1.226	-0.177	.007	.008	2	6
SKIN	GLIPR1 →	-2.438	-0.321	.004	.001	3	4
SKIN	NPHP4 →	+0.689	+0.215	.006	.005	3	4
SKIN	MOXD1 →	-2.930	-0.310	<.001	.004	3	4
BREAST	C1orf35 →	+0.731	+0.495	.001	.004	3	4
BREAST	PARP1 →	+0.898	+0.505	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072529 vs RBMS2 — LUNG_SCLC

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